![]() reported the cross-sectional PVS-to-vessel area ratio for pial vessels to be 1.4 for N = 13 mice, but they found considerable variation between samples. ![]() However, they did not characterize this variation and only reported a single average area measurement for arterial PVSs. They also found that PVSs varied in size depending on location, with larger PVSs in locations with multiple blood vessels or blood vessel bifurcations. The average PVS-to-vessel area was 1.26 for arteries compared to 0.13 for veins. The peak of the hydraulic resistance distribution is \(1.73\times 10^\) near veins. The area ratio was obtained across different cross sections, and we found that the distribution peaks for the original PVS and its closest idealized fit (polynomial fit) were 1.12 and 1.21, respectively. Three idealized geometric models were compared to PVSs imaged in vivo, and their accuracy in reproducing hydraulic resistances and PVS-to-vessel area ratios were evaluated. The hydraulic resistance per unit length of the PVS scales with the PVS cross-sectional area, and we found a power-law fit that predicts resistance as a function of the area. The ratio of PVS-to-vessel area varies widely across the cross sections analyzed. Based on the analysis, we propose an idealized model that approximates the cross-sectional size and shape of pial PVSs, closely matching their area ratios and hydraulic resistances. We segmented two-photon images of pial (surface) PVSs and the adjacent arteries and characterized their sizes and shapes of cross sections from 14 PVS segments in 9 mice. Thus, the size and shape of the perivascular spaces are essential parameters for models of CSF transport in the brain and require accurate quantification. ![]() The PVS geometry has important implications for CSF flow as it affects CSF and solute transport rates. Flow of cerebrospinal fluid (CSF) through brain perivascular spaces (PVSs) is essential for the clearance of interstitial metabolic waste products whose accumulation and aggregation is a key mechanism of pathogenesis in many diseases. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |